Milan look to Rafael Leao and Christopher Nkunku in attack, while Domenico Berardi returns to Sassuolo’s starting XI after serving a two-game ban.
It kicks off at 15:00 CET (14:00 BST) at the Mapei Stadium in Reggio Emilia.
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You can follow the build-up and live action as it happens on the Football Italia liveblog.
Milan must cope without Luka Modric, who has been forced to finish the season early due to a cheekbone injury that required surgery earlier this week.
MILAN, ITALY – APRIL 26: Rafael Leao of AC Milan warms up prior to the Serie A match between AC Milan and Juventus FC at Giuseppe Meazza Stadium on April 26, 2026 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
Ardon Jashari replaces the Croatian star in central midfield for the Rossoneri, while Christian Pulisic starts on the bench.
The USMNT star hasn’t yet scored a goal in 2026, so Massimiliano Allegri picks Leao and Nkunku up front.
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Fali Candè, Edoardo Pieragnolo, Daniel Boloca and Darryl Bakola, but their star winger Berardi returns to action after serving a two-game ban.
SASSUOLO, ITALY – FEBRUARY 20: Domenico Berardi of US Sassuolo celebrates after scoring his team’s third goal during the Serie A match between US Sassuolo Calcio and Hellas Verona FC at Mapei Stadium Citta del Tricolore on February 20, 2026 in Sassuolo, Italy. (Photo by Alessandro Sabattini/Getty Images)
Milan have a five-point lead over fifth-placed Como with a game in hand, but the Rossoneri have only won two of their last five league games.
Sassuolo vs. Milan – official line-ups
Sassuolo: Turati; Walukiewicz, Idzes, Muharemovic, Garcia; Thorstvedt, Matic, Koné; Berardi, Nzola, Laurienté
Milan: Maignan; Tomori, Gabbia, Pavlovic; Saelemaekers, Fofana, Jashari, Rabiot, Estupinan; Leao, Nkunku
