Sebastian Hoeneß makes four changes from the draw at Hoffenheim. Maximilian Mittelstädt, Chema Andrés, Nikolas Nartey and Ermedin Demirović come in for Joshua Vagnoman, Luca Jaquez, Atakan Karazor and Bilal El Khannouss.
Kasper Hjulmand has made one change from the commanding victory over RB Leipzig as Christian Kofane replaces Nathan Tella.
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Confirmed VfB Stuttgart vs. Bayer Leverkusen lineups
VfB Stuttgart (4-2-3-1): Nübel (GK) – Nartey, Hendriks, Chabot, Mittelstädt – Andrés, Stiller – Leweling, Undav, Führich – Demirović
Bayer Leverkusen (3-4-2-1): Flekken (GK) – Quansah, Andrich, Tapsoba – Culbreath, Garcia, Palacios, Grimaldo – Maza, Kofane – Schick
