Game 5 of the 2025 ALDS between the Detroit Tigers and Seattle Mariners goes down on Friday evening in the 2025 MLB playoffs. The Tigers evened this series 2-2 with a 9-3 win over the Mariners on Wednesday. George Kirby (10-8, 4.21 ERA) takes the hill for the Mariners, and Tarik Skubal (13-6, 2.21 ERA) counters for the Tigers. The winner will advance to play the Toronto Blue Jays in the ALCS.

First pitch from T-Mobile Park in Seattle is set for 8:08 p.m. ET. Detroit is a -120 favorite on the money line (risk $120 to win $100) in the latest Tigers vs. Mariners odds from DraftKings Sportsbook, with the Mariners as +100 underdogs. The total number of runs Vegas thinks will be scored, or the over/under, is 6. Before making any Tigers vs. Mariners picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model. 

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The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the second week of the 2025 MLB playoffs a profitable 35-29 on top-rated MLB money-line picks this season. It has excelled making home run prop picks this season, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Tigers vs. Mariners and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Tigers vs. Mariners:

Why the Mariners can win

Catcher Cal Raleigh is leading the team in batting average (.438), RBI (4) and hits (7) this postseason. In his last outing, Raleigh went 1-of-3 with a base hit and one run driven in. He has recorded a hit in every game this series and led the majors in home runs (60) during the regular season.

Shortstop J.P. Crawford has been another stable force this series, batting .300 with a homer and two runs driven in. In Game 3, he was 2-of-2 with a solo homer. Seattle is 8-4 as the home underdog and 52-31 as the home team this campaign. See which team to back at SportsLine.

Why the Tigers can win

Center fielder Javier Baez continues to be a quality playmaker for Detroit. This postseason, he leads the team in batting average (.346), OBP (.370), and hits (9). In his last game, Baez went 2-of-4 with a homer and four total RBI. He’s finished with a hit in six of the seven postseason games in 2025.

First baseman Spencer Torkelson is leading the team in RBI (6) this postseason. During the regular season, he also hammered 31 home runs and 78 RBI, highlighting his power at the plate. The Tigers are 64-50 after a win and 49-41 following a win. See which team to back at SportsLine. 

How to make Tigers vs. Mariners picks

SportsLine’s model is leaning Over on the total, projecting 8.2 runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Tigers vs. Mariners, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.